A modified approach for the site-selective direct C-6 arylation of benzylated uracil

Savitha, Bhaskaran and Reddy, Eeda Koti and Ananda Kumar, C. S. and Karuvalam, Ranjith P. and Padusha, M. Syed Ali and Bakulev, Vasiliy A. and Narasimhamurthy, K. H. and Sajith, Ayyiliath M. and Joy, Muthipeedika Nibin (2019) A modified approach for the site-selective direct C-6 arylation of benzylated uracil. Tetrahedron Letters, 60 (52). p. 151332. ISSN 0040-4039

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Abstract

An efficient methodology is reported for the regioselective C-6 arylation of protected uracil via the palladium catalyzed CH functionalization of 1-(4-methoxybenzyl)-3-methylpyrimidine-2,4(1H,3H)-dione with (hetero)aryl halides and boronic acids. Utilization of the Pd(OAc)2/Xantphos catalytic system with a stoichiometric amount of CuI and DBU as the base was vital for the success of this protocol. The methodology is facile and compatible with aryl bromides, iodides and boronic acids and hence affords broad substrate scope and diversity.

Item Type:	Article
Uncontrolled Keywords:	Uracil, CH functionalization, Palladium, Copper
Subjects:	D Physical Science > Material Science
Divisions:	Department of > Material Science
Depositing User:	C Swapna Library Assistant
Date Deposited:	19 Nov 2025 11:12
Last Modified:	19 Nov 2025 11:12
URI:	http://eprints.uni-mysore.ac.in/id/eprint/17933

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