Titrimetric and spectrophotometric methods for the assay of ketotifen using cerium(IV) and two reagents.

Raghu, M. S. and Basavaiah, K. and Prashanth, K. N. and Vinay, K. B. (2014) Titrimetric and spectrophotometric methods for the assay of ketotifen using cerium(IV) and two reagents. International Journal of Analytical Chemistry. pp. 1-9. ISSN 1687-8779

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Official URL: http://dx.doi.org/10.1155/2013/697651

Abstract

One titrimetric and two spectrophotometric methods are described for the determination of ketotifen fumarate (KTF) in bulk drugand in tablets using cerium(IV) as the oxidimetric agent. In titrimetry (method A), the drug was treated with a measured excess of cerium(IV) in H2SO4 medium and after a standing time of 10 min, the surplus oxidant was determined by back titration with iron(II). The spectrophotometric procedures involve addition of a known excess of cerium(IV) to KTF in acidmedium followed by the determination of unreacted oxidant by reacting with either p-dimethyl amino benzaldehyde and measuring the resulting colourat 460 nm(method B) or o-dianisidine and subsequent measurement of the absorbance of coloured product at 470nm (method C).Titrimetric assay is based on a 1 : 2 reaction stoichiometry between KTF and cerium(IV) and the method is applicable over 2–18mgrange. In spectrophotometry, regression analysis of Beer’s law plots showed a good correlation in 0.4–8.0 and 0.4–10.0 gm L−1KTF ranges for method B and method C, respectively, and the corresponding molar absorptivity coefficients are calculated to be 4.0×104and 3.7 × 104 Lmol−1 cm−1.

Item Type: Article
Additional Information: Unmapped bibliographic data: PY - 2014/// [EPrints field already has value set] M3 - 10.1155/2013/697651 [Field not mapped to EPrints] JA - Int. J. Anal. Chem. [Field not mapped to EPrints]
Subjects: Physical Sciences > Chemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Chemistry
Depositing User: Praveen Kumari B.L
Date Deposited: 16 May 2015 10:22
Last Modified: 16 May 2015 10:22
URI: http://eprints.uni-mysore.ac.in/id/eprint/17875

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