Angiotensin-I-converting enzyme inhibition and antioxidant activity of benzamide appended oxadiazole derivatives

Shilpa Patil, C. and Naik, Ravikumar N. and Satish, S. and Pramod, H. and Sudha B. Satyanarayana, (2014) Angiotensin-I-converting enzyme inhibition and antioxidant activity of benzamide appended oxadiazole derivatives. Indo American Journal of Pharmaceutical Research, 4 (7). pp. 3160-3166. ISSN 2231-6876

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In continuation of our research on the synthesis of benzamide appended heterocyclic compounds, here in some new benzamide appended oxadiazole derivatives (2a-i) were prepared and structures were confirmed by their spectral studies. ACE-I inhibition activity was investigated, Compounds 2a and 2i proved to be potent ACE-I inhibitors with IC50 value of 27.50 μg/μl and the compounds 2b-e showed moderate ACE-I inhibition with IC50 value in the range of 34-36 μg/μl when compared to standard lisinopril (IC50=30.83 μg/μl).. Compounds 2g-h exhibit least ACE inhibition activity with IC50 values of 41.66 μg/μl and 43.33 μg/μl . Antioxidant activities was probed by DPPH assay, lipid peroxidation assay and super radical scavenging activity. DPPH assay revealed that compounds 2a-e were moderate radical scavengers with IC50 value in the range of 16-20 μg/μl when compared to standard Ascorbic acid (IC50 value = 9.73μg/μl). The compounds 2a-f showed moderate anti-lipid peroxidation activity when compared to standard α-tocopherol (IC50 value = 30.47 mg/ml). By Superoxide radical scavenging assay, compounds 2a-g were found to be moderate superoxide radical scavengers with activity in the range of 35-29% when compared to standard Butylated hydroxyanisole (39.93%). By antioxidant assay it was proved that the compound 2h was potent radical scavenger.

Item Type: Article
Subjects: Agriculture Biological Sciences > Microbiology
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Microbiology

Physical Sciences > Chemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Microbiology
Depositing User: Praveen Kumari B.L
Date Deposited: 11 May 2015 05:17
Last Modified: 19 Jul 2016 05:28

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