Hegde, Pooja Lokesh and Bhat, Satish S. and Revankar, Vidyanand K. and Shaikh, Sabiha A. and Kumara, Karthik and Lokanath, N. K. (2022) Syntheses, structural characterization and evaluation of the anti-tubercular activity of copper (II) complexes containing 3-methoxysalicylaldehyde-4-methylthiosemicarbazone. Journal of Molecular Structure, 1257. ISSN 1872-8014
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In the present work three novel copper (II) complexes (CuL(CH3COO)] (1), CuL(phen)] (2) and CuL(bpy)] (3) (where phen=1,10-phenanthroline; bpy=2,2' bipyridyl)) containing 3-methoxysalicylaldehyde-4-methylthiosemicarbazone (HL) were synthesised and characterised. All the complexes were characterized using spectral techniques like FT-IR, ESI-MS, TGA-DTA, UV-Vis, ESR and VSM. The structure of complex 2 was confirmed by single-crystal X-ray structure determination. Complex 2 crystallized in a monoclinic crystal system and P 2(1)/n space group with a distorted square pyramidal geometry. In vitro anti-TB and cytotoxicity studies were also carried out using MABA (Microplate Alamar Blue Assay) and MIT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay, respectively. All the copper (II) complexes have shown excellent anti-TB properties in the nano-molar concentration range and exhibit low cytotoxicity. (C) 2022 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Copper complex; Thiosemicarbazone; Single-crystal X-ray diffraction; Mycobacterium tuberculosis H37Rv inhibition; Cytotoxicity; Selectivity index |
| Subjects: | D Physical Science > Physics |
| Divisions: | Department of > Physics |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 03 Oct 2023 06:10 |
| Last Modified: | 03 Oct 2023 06:10 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/17754 |
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