Microwave-Assisted Synthesis, Characterization, Docking Studies and Molecular Dynamic of Some Novel Phenyl Thiazole Analogs as Xanthine Oxidase Inhibitor

Jyothi, Mahima and Khamees, Hussien Ahmed and Patil, Shashank M. and Ramu, Ramith and Shaukath Ara Khanum (2022) Microwave-Assisted Synthesis, Characterization, Docking Studies and Molecular Dynamic of Some Novel Phenyl Thiazole Analogs as Xanthine Oxidase Inhibitor. Journal of the Iranian Chemical Society, 19 (9). pp. 3919-3933. ISSN 1735-2428

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Abstract

A series of novel substituted 2-(4-bromophenyl)-4-phenylthiazole compounds 5a-h were synthesized by a simplified two-step process. First, the selective and effective alpha-bromination of substituted acetophenone moieties with N-bromo succinamide was done followed by treating of substituted 2-bromo-1-phenylethan-1-one with 4-bromobenzothiamide under microwave irradiation. The structures of the newly synthesized compounds were confirmed by IR, H-1 NMR, C-13 NMR, mass spectra and C, H, N analysis. Further, all the synthesized compounds 5a-h were evaluated for xanthine oxidase inhibition. Among all the tested compounds, 5f was found to be highly potent (IC50 = 0.100 +/- 0.08 mu M) followed by 5e (IC50 = 0.145 +/- 1.42 mu M), compared to the standard allopurinol (IC50 = 0.150 +/- 0.07 mu M), which is evident from in vitro and in silico analysis.

Item Type:	Article
Uncontrolled Keywords:	Phenyl thiazole microwave synthesis; Xanthine oxidase inhibition; Docking study
Subjects:	C Chemical Science > Chemistry
Divisions:	Yuvaraj college > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	04 Sep 2023 07:24
Last Modified:	04 Sep 2023 07:24
URI:	http://eprints.uni-mysore.ac.in/id/eprint/17708

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