DNA binding, anti-inflammatory and analgesic evaluation of metal complexes of N/S/O donor ligands; Synthesis, spectral characterization

Naik, K. H. Kumar and Ashok, B. and Naik, Nagaraja and Mulla, Jameel Ahmed S. and Prakasha, Avinash (2015) DNA binding, anti-inflammatory and analgesic evaluation of metal complexes of N/S/O donor ligands; Synthesis, spectral characterization. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 141. pp. 88-93. ISSN 1386-1425

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Official URL: http://dx.doi.org/10.1016/j.saa.2014.11.068

Abstract

Transition metal complexes containing tri-dentate NSN donor ligands i.e., 5-((1(aminomethyl)cyclohexyl)methyl)-1,3,4-thiadiazol-2-amine (AMTA) (2) and 5-(2-aminophenyl)-1,3,4-thiadiazol-2-amine (ATA) (4i–ii) have been synthesized. The newly synthesized ligands and their respective complexes were characterized by elemental analysis, molar conductance measurement and various spectral studies [infrared (IR), electronic, and NMR (for ligands only)]. Metal complexes are like [M(AMTA)2], [M(ATA)2] type, where M = Mn(II), Co(II) and Cu(II). The proposed geometries of the complexes are octahedral in nature. The synthesized ligands and their complexes were exhibits effective anti-inflammatory, analgesic and DNA binding activities. All the tested compounds exhibited significant analgesic activity, whereas the compound 4i, 4(ia) and 4(iib) is equipotent with Diclofenac sodium.

Item Type: Article
Additional Information: Unmapped bibliographic data: PY - 2015/4/15/ [EPrints field already has value set] JO - Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy [Field not mapped to EPrints]
Uncontrolled Keywords: Ligands, Metal complexes, Analgesic activity, Anti-inflammatory activity, DNA binding studies
Subjects: Physical Sciences > Chemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Chemistry
Depositing User: Ms. Manjula p
Date Deposited: 10 Apr 2015 10:53
Last Modified: 15 Oct 2015 06:50
URI: http://eprints.uni-mysore.ac.in/id/eprint/17687

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