Saleh, E. A. M. and Kotian, S. Y. and Al Dawsari, A. M. and Hassan, I and Husain, K. and Abishad, P. C. and Byrappa, K. and Al Sharabi, R. S. S. and Rai, K. M. L. (2022) Synthesis, Antifungal, and Antioxidant Evaluation of New Class of Thiazoloquinazoline Linked by Carbonyl with Nitrile, Phenylacrylonitrile, Pyrazole, Pyrazolo1,5-a]pyrimidine and Triazolo1,5-a]pyrimidine as Five and Six-Membered Heterocycles Derivatives. Russian Journal of Bioorganic Chemistry, 48 (6). pp. 1299-1313. ISSN 1608-330X
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Abstract
A specific route for the synthesis of a novel benzo4,5]thiazolo2,3-b]quinazoline (IVa-e), (VIa-e), (VIIa-e), (VIIIa-e), (IXa-e), and (Xa-e) derivatives, where established using thiazolo2,3-b]quinazoline-3,6(5H,7H)-dione derivatives (Ia-e) as an efficient starting materials. The present report briefly outlines relevant synthetic methods employed for this class of new compounds and intensively reveals significant antifungal and antioxidant activities along with SAR studies. The results of this study indicate that the target compounds (VIIa-e) and (VIIIa-e) exhibited better antifungal activity at 100 mu g/ml compared with standard Trifloxystrobin and Azoxystrobin, respectively while compounds (IXa-f) particularly compound (IXd) showed good antioxidant activity at 10 mu g/mL. Structures of newly synthesized compounds were confirmed by elemental analysis and spectral IR, H-1 NMR and C-13 NMR.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | pyrido; pyrano; benzo; thiazolo and quinazoline |
| Subjects: | C Chemical Science > Biochemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 21 Jul 2023 05:34 |
| Last Modified: | 21 Jul 2023 05:34 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/17671 |
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