Synthesis, Antioxidant, and Antibacterial Activities of Two Novel Series of 3,5-Disubstituted Isoxazole Ether-Linked Isoxazolines and 3,5-Disubstituted Pyrazole Ether-Linked Isoxazolines Mediated by Chloramine-T

Saleh, E. A. M. and Kotian, S. Y. and Al Dawsari, A. M. and Hassan, I and Husain, K. and Abishad, P. C. and Byrappa, K. and Al Sharabi, R. S. S. and Rai, K. M. L. (2022) Synthesis, Antioxidant, and Antibacterial Activities of Two Novel Series of 3,5-Disubstituted Isoxazole Ether-Linked Isoxazolines and 3,5-Disubstituted Pyrazole Ether-Linked Isoxazolines Mediated by Chloramine-T. Russian Journal of Bioorganic Chemistry, 48 (5). pp. 1043-1052. ISSN 1608-330X

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Official URL: https://doi.org/10.1134/S1068162022050181

Abstract

Two short novel series of five membered heterocyclic 3,5-disubstituted-Isoxazole ether-linked Isoxazoline derivatives (Xa-f) and 3,5-disubstituted-Pyrazole ether-linked Isoxazoline derivatives (XIa-f) were synthesized via 1,3-dipolar cycloaddition reaction of Isoxazole ether-linked allyloxymethyl (VI) and pyrazole ether-linked allyloxymethyl (VII) with aromatic aldoximes (VIIIa-f) which undergo oxidative dehydrogenation with chloramine-T (IX) to give 3,5-disubstituted isoxazole ether-linked isoxazoline derivatives (Xa-f) and 3,5-disubstituted pyrazole ether-linked Isoxazoline derivatives (XIa-f) in good yield. The newly synthesized compounds were screened for anti-oxidant and anti-microbial activities. 3,5-Disubstituted isoxazole ether-linked isoxazoline derivatives (Xc-d) and 3,5-disubstituted Pyrazole ether-linked isoxazoline derivatives (XIc-d) exhibited antioxidant activity at 10 mu g/mL, as well as anti-microbial activity at 100 mu g/mL compared with standard vitamin C and ciprofloxacin, respectively. Structures of newly synthesized compounds were established on the basis of their elemental analysis and spectral IR, H-1 NMR, and C-13 NMR.

Item Type: Article
Uncontrolled Keywords: isoxazoles; pyrazoles; isoxazolines; ether-linked; chloramine-T; antioxidant; antibacterial
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: C Swapna Library Assistant
Date Deposited: 21 Jul 2023 04:38
Last Modified: 21 Jul 2023 04:38
URI: http://eprints.uni-mysore.ac.in/id/eprint/17664

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