The Mn(II), Co(II), Ni(II) and Cu(II) complexes of (Z)-N'((1H-indol-3-yl)methylene)nicotinohydrazide Schiff base: synthesis, characterization and biological evaluation

Neelufar and Rangaswamy, J. and Ankali, K. N. and Naik, Nagaraja and Nuthan, B. R. and Satish, S. (2022) The Mn(II), Co(II), Ni(II) and Cu(II) complexes of (Z)-N'((1H-indol-3-yl)methylene)nicotinohydrazide Schiff base: synthesis, characterization and biological evaluation. Journal of the Iranian Chemical Society, 19 (9). pp. 3993-4004. ISSN 1735-2428

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Abstract

Schiff bases being biological moieties possess diverse biological and pharmaceutical applications. Metal ions play an important role in various functions of the biological system as well as the human body. The importance of Schiff base and their metal complexes have been acknowledged in the field of bioinorganic chemistry. The current investigation hence focuses on the synthesis and characterization of a bidentate indole-based ligand(Z)-N'((1H-indol-3-yl)methylene)nicotinohydrazide (L) derived from indole-3-carboxaldehyde (1), nicotinic acid hydrazide (2) and their metal complexes of Mn(II), Co(II), Ni(II) and Cu(II), (4a-d) in 2:1 stichiometric ratio. All the synthesized ligand and complexes were characterized by IR, UV-Visible, H-1 NMR, C-13 NMR, Mass, Powder XRD analysis. Further, the ligand and their metal complexes were screened for antimicrobial, antioxidant and DNA cleavage studies. Among the synthesized complexes, Ni(II) (4c) showed highest antimicrobial activity against tested Gram -ve and Gram +ve bacterial strains and fungal microorganism, better than the ligand (L). The antioxidant activity results showed that the metal complexes (4a-d) were observed to be more active than the parent ligand. Furthermore, the ligand (L) and their respective metal (II) complexes (4a-d) were found to cleave the pBR322 DNA, during gel electrophoresis studies.

Item Type:	Article
Uncontrolled Keywords:	Indole; Schiff base; Metal complexes; Antimicrobial; Antioxidant; DNA cleavage; Biological activities
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	13 Jul 2023 06:29
Last Modified:	13 Jul 2023 06:29
URI:	http://eprints.uni-mysore.ac.in/id/eprint/17614

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