Athira, Vadakkepurath Raj and Shivanandappa, Thimmappa and Yajurvedi, Hanumant Narasinhacharya (2022) Cyclophosphamide, a cancer chemotherapy drug-induced early onset of reproductive senescence and alterations in reproductive performance and their prevention in mice. Drug and Chemical Toxicology, 45 (2). pp. 760-766.
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Although, cyclophosphamide (CP) treatment is known to cause degeneration of the ovarian follicular reserve, which may have a serious consequence of the onset of early reproductive senescence, thus far there is no experimental study either to demonstrate CP-induced early onset of reproductive senescence or its prevention. Intraperitoneal administration (ip) of CP [100 mg/kg body weight (bw)/mouse] resulted in a drastic reduction in reproductive life span as shown by the onset of reproductive senescence at a significantly early age (258 days) compared to controls (349 days), whereas treatment with the root extract of the herb Decalepis hamiltonii (DH) (200 mg/Kg bw/day for 7 days), a cocktail of anti-oxidants prior to CP administration maintained normal reproductive life span in mice. Further, the CP treated mice showed a significant increase in pre-coital interval and a significant reduction in parturition index coupled with regressive changes in the uterine endometrium, whereas DH co-treatment prevented these changes. The results for the first time, demonstrate that the ovarian toxicity of CP could be prevented by an anti-oxidant to maintain a normal reproductive life span as well as reproductive outcome using mice model.
| Item Type: | Article |
|---|---|
| Additional Information: | PMID: 32536211 |
| Uncontrolled Keywords: | Cyclophosphamide; Premature Ovarian Failure; Decalepis Hamiltonii; Reproductive Performance; Reproductive Senescence; Uterus |
| Subjects: | B Life Science > Zoology |
| Divisions: | Department of > Zoology |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 03 Jul 2023 07:11 |
| Last Modified: | 03 Jul 2023 07:11 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/17571 |
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