An expedient, efficient and solvent-free synthesis of T3P®-mediated amidation of benzhydrols with poorly reactive N-nucleophiles under MW irradiation

Cheruku, Srinivas and Sandhya, C. N. and Sunil kumar, M. P. and Yatheesh, N. and Kumara, N. M. and Rangappa, K. S. and Mantelingu, K. (2022) An expedient, efficient and solvent-free synthesis of T3P®-mediated amidation of benzhydrols with poorly reactive N-nucleophiles under MW irradiation. New Journal of Chemistry, 46. pp. 4421-4426.

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Official URL: http://dx.doi.org/10.1039/D1NJ04502D

Abstract

An expedient, efficient, economical, environmentally benign, and solvent free amidation protocol of benzhydrols with less reactive nitrogen nucleophiles assisted by propylphosphonic anhydride (T3P®) under microwave irradiation has been developed. The methodology has been deployed for a wide range of heterocycles and electron-withdrawing & electron-donating groups. The protocol resulted in good to excellent yields under the given conditions (26 examples, 68–93 yield).

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: C Swapna Library Assistant
Date Deposited: 01 Jul 2023 10:27
Last Modified: 01 Jul 2023 10:27
URI: http://eprints.uni-mysore.ac.in/id/eprint/17563

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