Ravi Singh, Krishna and Santhosh, C. and Swaroop, T. R. and Sadashiva, M. P. (2022) The regioselective synthesis of 2,5- and 4,5-disubstituted thiazoles via the cyclization of 2-oxo-2-(amino)ethanedithioates with isocyanides. Org. Biomol. Chem., 20. pp. 5771-5778. ISSN 1477-0539
Full text not available from this repository. (Request a copy)Abstract
The regioselective synthesis of 2-(methylthio)-N-aryl/alkylthiazole-5-carboxamides and ethyl-5-(aryl/alkyl carbamoyl)thiazole-4-carboxylates was carried out via the base-induced cyclization of methyl-2-oxo-2-(amino)ethanedithioates with TosMIC and ethyl isocyanoacetate, respectively, with high yields. The regioisomeric products were confirmed based on X-ray diffraction studies. An advantage of the present method is the wide-ranging isocyanide reactivity compared to earlier protocols, while the catalyst-free nature and rapid reaction times are noteworthy features.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 14 Jun 2023 05:54 |
| Last Modified: | 14 Jun 2023 05:54 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/17521 |
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