Naghshband, Zeinab and Malini, S. S. (2022) Association of FTO Gene Variant Rs9939609 with Hyperandrogenemia and Fasting Glucose levels in South Indian Women with Polycystic Ovarian Syndrome. Egyptian Journal of Medical Human Genetics, 23 (1).
Full text not available from this repository. (Request a copy)Abstract
Background: Polycystic ovary syndrome (PCOS) is a common endocrine–metabolic disorder due to genetic and environmental factors. Genetic variants located in intron 1 of Fat mass and obesity-associated (FTO) gene are associated with increased risk of obesity and metabolic disorders. This study aims to investigate the association of common FTO polymorphism rs9939609 in South Indian women with PCOS to assess its association with metabolic and endocrine parameters. FTO genotyping was done on 100 PCOS patients and 70 controls by Sanger sequencing. Results: The distribution of rs9939609 was observed between groups (28% TT, 57% TA, and 15% AA for PCOS and 37.1% TT, 51.4% TA, and 11.4% AA for the controls). In the PCOS group, across the carriers of different genotypes, a significant association was found between body mass index (BMI), fasting glucose levels, and testosterone with the presence of at least one risk allele of FTO rs9939609. Logistic regression analysis showed the association of fasting glucose levels and testosterone (OR 1.30 [1.03–1.63] and OR 5.83 [1.61–21.11], respectively) with FTO rs9939609. Conclusions: Our findings indicated that FTO SNP rs9939609 was not associated with PCOS, but suggested a signifi- cant association of rs9939609 with hyperandrogenemia, fasting glucose levels, and BMI in South Indian women with PCOS
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Polycystic ovary syndrome, FTO gene, Hyperandrogenemia, Fasting glucose, Body mass index |
| Subjects: | B Life Science > Zoology |
| Divisions: | Department of > Zoology |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 06 Jun 2023 08:05 |
| Last Modified: | 06 Jun 2023 08:05 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/17500 |
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