Synthesis and crystal structure studies of 5-(tri­fluoro­meth­yl)-1,3,4-thia­diazol-2(3H)-one at 180 K

Geetha, D. and Mohan Kumar, T. M. and Anil Kumar, H. G. and Shreenivasa, M. T. and Basavaraju, Y. B. and Yathirajan, H. S. and Parkin, Sean (2023) Synthesis and crystal structure studies of 5-(tri­fluoro­meth­yl)-1,3,4-thia­diazol-2(3H)-one at 180 K. Acta Crystallographica Section E, 79 (6). pp. 557-561. ISSN 2056-9890

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Abstract

The synthesis and crystal structure of C3HF3N2OS, systematic name 5-(tri­fluoro­meth­yl)-1,3,4-thia­diazol-2(3H)-one (5-TMD-2-one), a compound containing the pharmacologically important heterocycle 1,3,4-thia­diazole, is presented. The asymmetric unit comprises six independent mol­ecules (Z′ = 6), all of which are planar. The r.m.s. deviations from each mean plane range from 0.0063 to 0.0381 Å, not including the CF3 fluorine atoms. Within the crystal, two of the mol­ecules form hydrogen-bonded dimers that in turn combine with inversion-related copies to form tetra­meric constructs. Similar tetra­mers, but lacking inversion symmetry, are formed by the remaining four mol­ecules. The tetra­mers are linked into tape-like motifs by S⋯O and O⋯O close contacts. The environments of each symmetry-independent mol­ecule were compared via a Hirshfeld surface analysis. The most abundant atom–atom contacts are between fluorine atoms, while the strongest result from N—H⋯O hydrogen bonds.

Item Type:	Article
Uncontrolled Keywords:	1,3,4-thiadiazole, heterocycle, high Z', Z' = 6, hydrogen bonding, disorder, crystal structure
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	01 Jun 2023 10:12
Last Modified:	01 Jun 2023 10:12
URI:	http://eprints.uni-mysore.ac.in/id/eprint/17495

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