Titrimetric assay of zolmitriptan in non-aqueous medium

Prashanth, Kudige N. and Swamy, Nagaraju (2014) Titrimetric assay of zolmitriptan in non-aqueous medium. International Journal of Pharmaceutical and Chemical Sciences, 3 (2). pp. 384-390. ISSN 2277-5005

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Based on the nitrogenous base or tertiary amine moiety in zolmitriptan (ZMT), an anti-migraine drug,two highly accurate and selective titrimetric methods are proposed for the determination of ZMT inbulk drug and pharmaceuticals. In these methods, the drug dissolved in glacial acetic acid, wastitrated with acetous perchloric acid and end point determined either visually by using crystal violetindicator (method A) or potentiometrically by using combined glass-SCE electrode (method B). Boththe methods are applicable over the concentration range of 1.0-10.0 mg of ZMT. Calculations arebased on 1:1 molar ratio i.e., ZMT: HClO4, owing to the presence of one tertiary nitrogen atom. Theprocedures were applied to determine ZMT in its tablets and the results were found to be in goodagreement with those obtained by the reference method. Associated pharmaceutical materials did notinterfere. The precision results, expressed by inter-day and intra-day relative standard deviationvalues, were satisfactory (≤ 1.77%). Accuracy was satisfactory as well. The accuracy and reliability ofthe methods were further ascertained by recovery studies via standard addition technique withpercent recoveries in the range 98.00 - 102.0 % with standard deviation of less than 0.15%.

Item Type: Article
Subjects: Physical Sciences > Chemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Chemistry
Depositing User: Praveen Kumari B.L
Date Deposited: 24 Jan 2015 10:08
Last Modified: 24 Jan 2015 10:08
URI: http://eprints.uni-mysore.ac.in/id/eprint/17396

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