Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19

Fu, Jiewen and Wei, Chunli and He, Jiayue and Zhang, Lianmei and Zhou, Ju and Balaji, K. S. and Shen, Shiyi and Peng, Jiangzhou and Sharma, Amrish and Fu, Junjiang (2021) Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19. International Journal of Biological Sciences, 17 (3). pp. 897-910.

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HSPA5 (BiP, GRP78) has been reported as a potential host-cell receptor for SARS-Cov-2, but its expression profiles on different tissues including tumors, its susceptibility to SARS-Cov-2 virus and severity of its adverse effects on malignant patients are unclear. In the current study, HSPA5 has been found to be expressed ubiquitously in normal tissues and significantly increased in 14 of 31 types of cancer tissues. In lung cancer, mRNA levels of HSPAS were 253-fold increase than that of ACE2. Meanwhile, in both malignant tumors and matched normal samples across almost all cancer types, mRNA levels of HSPAS were much higher than those of ACE2. Higher expression of HSPAS significantly decreased patient overall survival (OS) in 7 types of cancers. Moreover, systematic analyses found that 7.15% of 5,068 COVID-19 cases have malignant cancer coincidental situations, and the rate of severe events of COVID-19 patients with cancers present a higher trend than that for all COVID-19 patients, showing a significant difference (33.33% vs 16.09%, p<0.01). Collectively, these data imply that the tissues with high HSPA5 expression, not low ACE2 expression, are susceptible to be invaded by SARS-CoV-2. Taken together, this study not only indicates the clinical significance of HSPA5 in COVID-19 disease and cancers, but also provides potential clues for further medical treatments and managements of COVID-19 patients.

Item Type: Article
Uncontrolled Keywords: cancer; HSPA5; prognostics; SARS-CoV-2; transcriptomics
Subjects: B Life Science > Biotechnology
Divisions: Department of > Biotechnology
Depositing User: Mr Umendra uom
Date Deposited: 10 May 2022 09:47
Last Modified: 27 May 2022 05:15
URI: http://eprints.uni-mysore.ac.in/id/eprint/17248

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