Basavanna, V. and Chandramouli, M. and Kempaiah, C. and Bhadraiah, U. K. and Chandra and Lingegowda, N. S. and Shridevi, D. and Ningaiah, S. (2021) A new series of 1,3,4-oxadiazole linked quinolinyl-pyrazole/isoxazole derivatives: synthesis and biological activity evaluation. Russian Journal of General Chemistry, 91 (11). pp. 2257-2266.
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Abstract
A series of 1,3,4-oxadiazole bridged pyrazole/isoxazole bearing quinoline derivatives has been designed and synthesized by a clean and convenient method. Structures of the newly synthesized compounds have been confirmed by FTIR, H-1 and C-13 NMR, and HRMS spectral data. The titled compounds have been evaluated for their molecular docking guided antimicrobial and anti-inflammatory activity. One of 1,3,4-oxadiazole bridged quinolinyl-pyrazole derivatives has interacted efficiently with E. Coli protein (PDB file: 1KZN), and has been characterized by good antimicrobial activity against the majority of the tested pathogens. Another product has exhibited excellent anti-inflammatory activity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1; 3; 4-oxadiazole; pyrazole; isoxazole; quinoline; molecular docking; antimicrobial; anti-inflammatory |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Yuvaraj college > Chemistry |
| Depositing User: | Mr Umendra uom |
| Date Deposited: | 10 May 2022 09:42 |
| Last Modified: | 24 Jun 2022 10:30 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/17247 |
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