Synthesis, structure–activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents

Mahantesha, B. and Jambagi, Vishwanath B. and Nivedita N. Barigidad, and Laxmeshwar, S. S. and Devaru, Venkatesh and Narayanachar, (2014) Synthesis, structure–activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents. European Journal of Medicinal Chemistry, 74. pp. 225-233. ISSN 0223-5234

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Official URL: http://dx.doi.org/10.1016/j.ejmech.2013.12.061

Abstract

A series of new iodinated-4-aryloxymethylcoumarins 6, 8 and 10 have been obtained from the reaction of various 4-bromomethylcoumarins 4 with 2-iodophenol 5, 3-iodophenol 7 and 4-iodophenol 9 respectively. All the title compounds were screened for anticancer activity against two cancer cell lines (MDA-MB human adenocarcinoma mammary gland and A-549 human lung carcinoma) and two mycobacterial strains (Mycobacterium tuberculosis H37 RV and Mycobacterium phlei). The SAR results indicate that nine compounds are potent, among these 10h and 10i having chlorine are most effective. This is the first report assigning in vitro anti-mycobacterial, anticancer and structure–activity relationship for this new class of iodinated-4-aryloxymethyl-coumarins.

Item Type: Article
Additional Information: Unmapped bibliographic data: PY - 2014/3/3/ [EPrints field already has value set] JO - European Journal of Medicinal Chemistry [Field not mapped to EPrints]
Uncontrolled Keywords: Coumarin, Heterocycles, Iodine, Anticancer, Anti-mycobacterial, SAR
Subjects: Physical Sciences > Polymer Science
Divisions: PG Campuses > PG Center, Mandya > Polymer Science
Depositing User: Praveen Kumari B.L
Date Deposited: 14 Jul 2014 07:19
Last Modified: 14 Jul 2014 07:19
URI: http://eprints.uni-mysore.ac.in/id/eprint/17083

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