Basavaiah, K. and Krishnamurthy, G. (1999) Oxidimetric titration of some phenothiazine neuroleptics and antiallergics with potassium dichromate. Analytical Sciences, 15 (1). pp. 67-71.
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Oxidimetric titration of some phenothiazine neuroleptics and antiallergics with potassium dichromate.pdf Restricted to Registered users only Download (30kB) | Request a copy |
Abstract
Three simple, rapid and accurate titrimetric procedures using potassium dichromate as titrant are described for the determination of six phenothiazine drugs in a pure form and in dosage forms. The procedures are based on the oxidation of phenothiazines in an acid medium to colorless sulfoxides via orange- or purple-colored intermediates. In the first method, phenothiazines are titrated directly in a H2SO4 medium to a colorless end-point. In the second procedure, a known excess of oxidant is added, and after a specified time the residual oxidant is determined iodometrically. The third method employs potentiometric end-point detection. The optimum reaction conditions and other analytical parameters are evaluated and the molar-ratio of the reaction is also calculated. The influence of the substrates commonly employed as excipients with phenothiazine drugs has been studied. A statistical comparison of the results obtained for pure drugs with those of an official method shows excellent agreement and indicates no significant difference in precision.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 23 not found. |
| Date Deposited: | 14 Jun 2021 08:29 |
| Last Modified: | 14 Jun 2021 08:29 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/16830 |
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