Spectrophotometric determination of ceterizine hydrochloride with Alizarin Red S

Basavaiah, K. and SriLatha and Swamy, J.M. (1999) Spectrophotometric determination of ceterizine hydrochloride with Alizarin Red S. Talanta, 50 (4). pp. 887-892.

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Official URL: https://doi.org/10.1016/S0039-9140(99)00179-4


A simple, rapid and sensitive spectrophotometric method has been developed for the assay of ceterizine hydrochloride (CTZH) in bulk drug and its pharmaceutical preparations. This method is based on the ion-pair complex reaction between CTZH and Alizarin Red S in Clarks-Lubs buffer. The chromogen being extractable with chloroform, could be measured quantitatively at 440 nm. All variables were studied to optimise the reaction conditions. Regression analysis of Beer's Law plot showed good correlation in the concentration range 2.5-22 mu g ml(-1). The method has a detection limit of 0.1328 mu g ml(-1). The proposed method has been successfully applied for the analysis of the bulk drug and its dosage forms such as tablets and syrups. No interference was observed from common pharmaceutical adjuvants. (C) 1999 Elsevier Science B.V. All rights reserved.

Item Type: Article
Additional Information: Workshop on Methodologies for Wastewater Quality Monitoring, NIMES, FRANCE, OCT 29-30, 1998
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Users 23 not found.
Date Deposited: 21 Jun 2021 07:11
Last Modified: 21 Jun 2021 07:11
URI: http://eprints.uni-mysore.ac.in/id/eprint/16760

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