Kemparaju, K. and Krishnakantha, T. P. and Veerabasappa Gowda, T. (1999) Purification and characterization of a platelet aggregation inhibitor acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) venom. Toxicon, 37 (12). pp. 1659-1671.
![[img]](http://eprints.uni-mysore.ac.in/style/images/fileicons/text.png) |
Text
Purification and characterization of a platelet aggregation inhibitor acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) venom.pdf Restricted to Registered users only Download (152kB) | Request a copy |
Abstract
An acidic phospholipase A(2) (EC-I-PLA(2)) has been purified from the Indian saw-scaled viper (Echis carinatus) venom through a combination of column chromatography and electrophoresis. EC-I-PLA(2) has a molecular weight of 16000 by SDS-PAGE. It was focussed between pH 4.2 and 4.8 by isoelectro focussing. EC-I-PLA(2) was non-lethal to mice and devoid of neurotoxicity, myotoxicity, anticoagulant activity and cytotoxicity. It induced mild oedema in the foot pads of mice. The purified PLA(2) inhibited ADP, collagen and epinephrine induced human platelet aggregation and the inhibition was both dose and time dependent. (C) 1999 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Biochemistry |
| Divisions: | Department of > Biochemistry |
| Depositing User: | Users 23 not found. |
| Date Deposited: | 21 Jun 2021 07:04 |
| Last Modified: | 12 Jul 2022 06:18 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/16759 |
Actions (login required)
 |
View Item |
