Spectrophotometric determination of some antidepressant drugs using 3-methylbenzothiazolin-2-one hydrazone

Revanasiddappa, H.D. and Manju, B. (1999) Spectrophotometric determination of some antidepressant drugs using 3-methylbenzothiazolin-2-one hydrazone. European Journal of Pharmaceutical Sciences, 9 (2). pp. 221-225.

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Official URL: https://doi.org/10.1016/S0928-0987(99)00056-1

Abstract

A sensitive spectrophotometric method for the determination of amitriptyline hydrochloride, nortriptyline hydrochloride and doxepin hydrochloride in pure and dosage forms, is described. The method is based on the oxidative coupling of the drugs with 3-methylbenzothiazolin-2-one hydrazone in the presence of iron(III) chloride in 1 M hydrochloric acid. The commonly encountered excipients and additives do not interfere with the determinations. Results of the present method are comparable with those of official methods. The new method offers the advantage of simplicity and rapidity. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: lpa venkatesh user
Date Deposited: 23 Jun 2021 09:14
Last Modified: 23 Jun 2021 09:14
URI: http://eprints.uni-mysore.ac.in/id/eprint/16752

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