Synthesis and tumor inhibitory activity of novel coumarin analogs targeting angiogenesis and apoptosis

Vijay Avin, B. R. and Thirusangu, Prabhu and Lakshmi Ranganatha, V. and Firdouse, Aiyesha and Prabhakar, B. T. and Khanum, Shaukath Ara (2014) Synthesis and tumor inhibitory activity of novel coumarin analogs targeting angiogenesis and apoptosis. European Journal of Medicinal Chemistry, 75. pp. 211-221. ISSN 0223-5234

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Official URL: http://dx.doi.org/10.1016/j.ejmech.2014.01.050

Abstract

A sequence of coumarin analogs 5a-j was obtained by multi step synthesis from hydroxy benzophenones (1a-j). The in vitro antiproliferative effect of the title compounds was tested against Ehrlich ascites carcinoma (EAC) and Daltons lymphoma ascites (DLA) cell lines. Among the series, compound 5c with bromo group in the benzophenone moiety was endowed with excellent antiproliferative potency with significant IC50 value. Further, in vivo antitumor effect of compound 5c against murine EAC and solid DL tumor model system was evident by the extended survivality. The tumor inhibitory mechanism of compound 5c was due to the antiangiogenesis and promotion of apoptosis. These results suggest possible applications of compound 5c which could be developed as a potent anticancer drug in the near future.

Item Type: Article
Additional Information: Unmapped bibliographic data: PY - 2014/3/21/ [EPrints field already has value set] JO - European Journal of Medicinal Chemistry [Field not mapped to EPrints]
Uncontrolled Keywords: Coumarin analogs, Antitumor, Antiangiogenic, Proapoptotic
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry

Physical Sciences > Chemistry
Divisions: Constituent Colleges > Yuvaraja's College Mysore > Biochemistry
Constituent Colleges > Yuvaraja's College Mysore > Chemistry
Depositing User: Praveen Kumari B.L
Date Deposited: 02 Jun 2014 10:42
Last Modified: 02 Jun 2014 10:42
URI: http://eprints.uni-mysore.ac.in/id/eprint/16749

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