Spectrophotometric method for the determination of paracetamol and phenacetin

Nagaraja, P. and Srinivasa Murthy, K. C. and Rangappa, K. S. (1998) Spectrophotometric method for the determination of paracetamol and phenacetin. Journal of Pharmaceutical and Biomedical Analysis, 17 (3). pp. 501-506. ISSN 0731-7085

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Official URL: https://doi.org/10.1016/S0731-7085(97)00237-9


A rapid, sensitive and simple spectrophotometric method is proposed for the determination of hydrolysis products of paracetamol (PRL) and phenacetin (PHN) with sodium 1,2-naphthoquinone-4-sulphonate and cetyltrimethyl ammonium bromide (CTA) in alkaline medium. The absorbances are measured at 570 and 500 nm and the molar absorptivities found to be 1.118 x 10(4) and 4.54 x 10(3) l mol(-1) cm(-1) for PRL and PHN, respectively. The coloured species conforms to Beer's law over the range 1-20 mu g ml(-1) for PRL and 2-24 mu g ml(-1) of PHN. The sensitivity is enhanced by the addition of CTA. The method is successfully employed for determination of PRL or PHN in various pharmaceutical preparations and laboratory made tablets and results have been statistically compared with those obtained by the official method. (C) 1998 Published by Elsevier Science B.V. All rights reserved.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Users 23 not found.
Date Deposited: 07 Jun 2021 06:43
Last Modified: 04 Jul 2022 06:14
URI: http://eprints.uni-mysore.ac.in/id/eprint/16708

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