Titrimetric micro determination of some phenothiazine neuroleptics with potassium hexacyanoferrate(III)

Basavaiah, K. and Krishnamurthy, G. (1998) Titrimetric micro determination of some phenothiazine neuroleptics with potassium hexacyanoferrate(III). Talanta, 47 (1). pp. 59-66.

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Official URL: https://doi.org/10.1016/S0039-9140(98)00057-5


Three simple, rapid and accurate titrimetric procedures using potassium hexacyanoferrate(III) have been developed for the micro determination of five phenothiazine drugs in pure form and in dosage forms. The procedures are based on the oxidation of phenothiazines in an acid medium to colourless sulphoxides via orange or purple coloured products. In the first procedure, phenothiazines are titrated directly in H2SO4-H3PO4 medium to a colourless end point. In the second method, a known excess of the oxidant is added and after a specified time, the residual oxidant is determined iodometrically. The third method employs electrometric end-paint detection. The optimum reactions conditions and other analytical parameters are evaluated. The influence of the substrates commonly employed as excipients with phenothiazine drugs has been studied. Statistical comparison of the results with those of an official method shows excellent agreement and indicates no significant difference in precision. (C) 1998 Elsevier Science B.V. All rights reserved.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Users 23 not found.
Date Deposited: 08 Jun 2021 08:03
Last Modified: 08 Jun 2021 08:03
URI: http://eprints.uni-mysore.ac.in/id/eprint/16698

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