Liquid secondary ionization mass spectrometry and collision-induced dissociation study of 2-chloro-N10-substituted phenoxazines

Dass, Chhabil and Thimmaiah, K. N. and Jayashree, B. S. and Houghton, Peter J. (1997) Liquid secondary ionization mass spectrometry and collision-induced dissociation study of 2-chloro-N10-substituted phenoxazines. Journal of Mass Spectrometry, 32 (12). pp. 1279-1289.

Text Liquid secondary ionization mass spectrometry and collision-induced dissociation study of 2-chloro-N10-substituted phenoxazines.pdf Restricted to Registered users only Download (467kB) | Request a copy

Abstract

Positive-ion liquid secondary ionization mass spectrometry in combination with 3-nitrobenzyl alcohol as the liquid matrix was used to investigate the mass spectral features of a set of 21 N-10-substituted derivatives of 2-chlorophenoxaine. The N-10 substitution included propyl, butyl and acetyl groups containing various secondary amines (N,N-diethylamine, N,N-diethanolamine, morpholine, piperidine, pyrrolidone or beta-hydroxyethylpiperazine) or a chloro group, These compounds are potent multi-drug resistance modulators, The molecular ions are observed as M+. and M + H](+) ions, In general, the fragmentation pathways of these molecules are similar and very straightforward. The phenoxazine ring system remains stable under the Cs+ ion beam bombardment conditions, while fragmentations are observed along the length of the alkyl and acetyl side-chains, The fragmentation reactions were corroborated by acquiring product ion and constant neutral loss tandem mass spectrometric scans of the pertinent ions. (C) 1997 John Wiley & Sons, Ltd.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Users 23 not found.
Date Deposited:	05 Jun 2021 05:54
Last Modified:	09 Sep 2022 11:10
URI:	http://eprints.uni-mysore.ac.in/id/eprint/16585

Actions (login required)

View Item