cis-(+/-)-5-2-(Dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3 ,4,5-tetrahydro-1,5-benzothiazepin-4-one

Kumaradhas, P. and Nirmala, K.A. and Sridhar, M.A. (1996) cis-(+/-)-5-2-(Dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3 ,4,5-tetrahydro-1,5-benzothiazepin-4-one. Acta Crystallographica Section C Structural Chemistry, 52 (10). pp. 2595-2597.

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The title compound, C20H24N2O3S, is a drug intermediate of diltiazem. The molecule is stabilized by covalent bonding and weak hydrogen bonding, and the crystal packing is stabilized by hydrogen bonding. The seven-membered ring is distorted showing a twist-boat conformation. The methoxyphenyl and hydroxy groups are cis oriented with respect to one another, with the phenyl ring in an axial position. Intermolecular hydrogen bonding produces dimers in the crystal.

Item Type: Article
Subjects: D Physical Science > Physics
Divisions: Department of > Physics
Depositing User: Users 23 not found.
Date Deposited: 24 May 2021 05:56
Last Modified: 24 May 2021 05:56

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