Dendrimer a New Dimension in Targeting Biofilms.

Zarena, A. S. and Shubha Gopal, (2013) Dendrimer a New Dimension in Targeting Biofilms. Mini-Reviews in Medicinal Chemistry, 13 (10, Co). pp. 1448-1461. ISSN 1389-5575

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Biofilms prevail in natural and man-made environment on all surfaces. They play a beneficial role in water treatment, waste management and are important reservoirs of pathogens involved in fouling of medical and industrial equipments. Biofilms are resistant to antimicrobial agents and there is a lack of understanding in combating these communities. With the advent of dendrimer this scenario has shown promising change. Dendrimers are complex 3D structure mols. that provide well defined functionality with potential application. Although the studies regarding dendrimer technol. are in infancy it serves as an attractive feature for drug encapsulation, binding and delivery to the target site. The synthesis of dendrimers is cumbersome and suffers from certain shortcomings such as extensive purifn., lower yield and steric hindrance. However, these drawbacks are overcome by engineering alteration in the dendritic structure. In this review we focus on the biol. application of dendrimer derived from peptide, carbohydrate, quaternary ammonia and metal ion in inhibiting biofilm formation and antimicrobial activities. [on SciFinder(R)]

Item Type: Article
Additional Information: Unmapped bibliographic data: PY - 2013/// [EPrints field already has value set] M3 - 10.2174/13895575113139990064 [Field not mapped to EPrints] JA - Mini-Rev. Med. Chem. [Field not mapped to EPrints]
Subjects: Agriculture Biological Sciences > Microbiology
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Microbiology
Divisions: PG Campuses > Manasagangotri, Mysore > Microbiology
Depositing User: Dhruvakumar
Date Deposited: 29 Jan 2014 09:27
Last Modified: 16 May 2015 10:32

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