DNA/BSA interaction and in vitro antimicrobial studies of Mn(III) complexes bearing bidentate N, O donor Schiff bases

Sharma, Disha and Revanasiddappa, H. D. and Jayalakshmi, B. (2020) DNA/BSA interaction and in vitro antimicrobial studies of Mn(III) complexes bearing bidentate N, O donor Schiff bases. Journal of the Iranian Chemical Society, 17 (1). pp. 43-58.

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Abstract

Eight new coordination compounds of Mn(III) with (E)-2-((3-(benzyloxypyridinylimino) methyl)-4-bromophenol (L1), (E)-2-((3-(benzyloxypyridinylimino) methyl)-4-chlorophenol (L2), (E)-2-((3-(benzyloxypyridinylimino) methyl)-6-methoxyphenol (L3) and (E)-2-((3-(bezyloxypyridinylimino) methyl)-4-bromo-6-methoxyphenol (L4) have been synthesized in two different ratio such as 1:2 ratio metal: ligands (L1-L4)] and using 1,10-phenanthroline (Phen) as an auxiliary ligand for 1:1:1 ratio ligands (L1-L4): metal: phen]. Newly prepared Mn(III) complexes are well characterized by elemental analysis, magnetic moment, molar conductance, H-1 and C-13 NMR, electronic absorption, infrared spectra, mass and TGA methods. The complexes having distorted octahedral geometry with N, O as donor site from Schiff base and N, N bestowed from the neutral ligand phenanthroline. The synthesized ligands and their Mn(III) complexes were subjected for antimicrobial assay. The ligands L1-L4 and all complexes (C1-C8) are proclaimed competent antimicrobial activities. The interaction of C1-C8 complexes with calf thymus DNA (CT-DNA) was ascertained by absorption titration, fluorescence spectra and viscosity measurements. Results have recommended that complexes bind to CT-DNA via an intercalative mode. The interaction of these synthesized complexes with BSA was also investigated using various spectroscopic techniques. Static mode of interactions was suggested for BSA binding with the complexes.

Item Type:	Article
Uncontrolled Keywords:	Bidentate Schiff base; Mn(III) complexes; Calf thymus DNA binding; BSA binding; Antimicrobial activity
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Mr Umendra uom
Date Deposited:	01 Feb 2021 10:01
Last Modified:	06 Feb 2023 10:10
URI:	http://eprints.uni-mysore.ac.in/id/eprint/15670

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