Bhat, Mahesh and Belagali, S. L. (2020) Structural Activity Relationship and Importance of Benzothiazole Derivatives in Medicinal Chemistry: A Comprehensive Review. Mini-Reviews in Organic Chemistry, 17 (3). pp. 323-350. ISSN 1570-193X
Full text not available from this repository. (Request a copy)Abstract
Benzothiazole (1, 3-benzothiazole) is one of the heterocyclic compounds, which is a weak base having varied biological activities. The unique methine center present in the thiazole ring makes benzothiazole as the most important heterocyclic compound. It is a common and integral structure of many natural and synthetic bioactive molecules. Benzothiazole derivatives show a variety of activities, with less toxic effects and their derivatives showed enhanced activities, which has proven Benzothiazole scaffold as one of the important moieties in medicinal chemistry. Benzothiazole ring containing compounds possess various pharmacological activities such as anti-viral, anti-microbial, antiallergic, anti-diabetic, anti-tumor, anti-intlammatory, anthelmitic and anti-cancer, which makes benzothiazole a rapidly developing and interesting compound in the medicinal chemistry. This review briefly explains the importance, common methods of synthesis of the benzothiazole scaffold and also explains the popular benzothiazole molecules which have applications in various fields of chemistry. A review has been carried out based on various pharmacological activities containing benzothiazole moieties and rationalize the activities based on the structural variations. Literature on benzothiazole derivatives reveals that substitution on the C-2 carbon atom and C-6 are the reasons for a variety of biological activities.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Anti-Alzheimer; anti-inflammatory; anticancer; antimicrobial; benzothiazole; heterocyclic compounds |
| Subjects: | B Life Science > Environmental Science |
| Divisions: | Department of > Environmental Science |
| Depositing User: | Mr Umendra uom |
| Date Deposited: | 02 Feb 2021 06:04 |
| Last Modified: | 01 Jul 2022 11:07 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/15661 |
Actions (login required)
 |
View Item |
