Dukanya and Swaroop, T. R. and Rangappa, K. S. and Basappa (2020) Cyclocondensation of Sodium Azide with Methyl N(N),N `-di(tri)substituted Carbamimidothioate : A New Dimension for the Synthesis of 1,5-disubstituted Tetrazoles and Their Cytotoxicity against Human Breast Cancer Cells. Current Organic Chemistry, 24 (23). pp. 2792-2799.
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Synthesis of 1,5-disubstituted tetrazoles by the cyclization of sodium azide with N(N),N'-di(tri)substituted carbamimidothioate is reported. Tetrazoles are obtained in good to excellent yield in the absence of a catalyst. All the compounds were characterized by NMR and HRMS analysis. Single crystal X-ray diffraction data of 1-(4-chlorophenyl)-4-(5-phenylIH-tetrazol-1-yl)piperazine 5g is also provided. Further, these disubstituted tetrazoles were tested against the proliferation of human breast cancer cells (MCF-7), which identified 5e as a lead compound. Finally, we have shown in silico that these compounds may interact with the ligand binding domain of estrogen receptor alpha (ER alpha), that expresses at high amount in MCF-7 cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Cyclocondensation; carbamimidothioates; sodium azide; tetrazoles; cytotoxicity; MCF-7 |
| Subjects: | C Chemical Science > Organic Chemistry |
| Divisions: | Department of > Organic Chemistry |
| Depositing User: | Mr Umendra uom |
| Date Deposited: | 03 Feb 2021 05:57 |
| Last Modified: | 02 Nov 2022 06:17 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/15656 |
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