Askari, Banafshe and Rudbari, Hadi Amiri and Valente, Andreia and Bruno, Giuseppe and Micale, Nicola and Naveen, S. and Lokanath, N. K. (2020) Synthesis, Characterization and Anticancer Studies of Rh(I), Rh(III), Pd(II) and Pt(II) Complexes Bearing A Dithiooxamide Ligand. Chemistry Select, 5 (2). pp. 810-817. ISSN 2365-6549
Full text not available from this repository. (Request a copy)Abstract
Breast cancer is the most common type of cancer in women. In the current study, six transition-metal complexes were reacted with a secondary dithiooxamide (H-2-isopropyl(2)DTO) to obtain the corresponding mononuclear complexes (1-6) and their cytotoxicity was evaluated in two human breast cancer cell lines, i. e. MCF-7 and MDA-MB-231. The characterization of the complexes, LnM(H-isopropyl(2) DTO kappa-S,S M)] (LnM=(C5Me5)RhCl, (1); (COD)Rh, (2); (eta(3)-allyl)Pd, (3); (tri(n)propyl-phosphine)PdCl, (4); (bpy)Pt, (5) and (pph(3))PtCl, (6)), and the ion pair form of 1-4, IP1-IP4, were accomplished through NMR spectroscopy and elemental analysis. The structures of 1 and IP1 were also determined by single crystal XRD technique. In vitro cytotoxicity studies in MCF-7 and MDA-MB-231 (IC50 determination) showed that all complexes are cytotoxic for both cell lines, with the exception of 2. Compound 3 was the most cytotoxic in the conditions tested. In addition, the compounds induce cell death by apoptosis and inhibit the formation of colonies, indicating that these compounds could provide promising new lead derivatives for anticancer drug development.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Breast cancer; MCF-7; MDA-MB-231; Palladium; Platinum; Rhodium; Secondary dithiooxamide |
| Subjects: | D Physical Science > Physics |
| Divisions: | Department of > Physics |
| Depositing User: | Mr Umendra uom |
| Date Deposited: | 04 Feb 2021 07:00 |
| Last Modified: | 01 Jun 2023 10:40 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/15651 |
Actions (login required)
 |
View Item |
