An efficient synthesis of medicinally important indole based triarylmethanes by using propylphosphonic anhydride (T3P (R))

Cheruku, Srinivas and Nagaraju, Chaithra and Shetty, Poornima and Hassan, Swarup A. and Nagarakere, Sandhya C. and Manikyanally, Kumara N. and Kempegowda, Mantelingu (2020) An efficient synthesis of medicinally important indole based triarylmethanes by using propylphosphonic anhydride (T3P (R)). Synthetic Communications, 50 (10). pp. 1486-1494. ISSN 1532-2432

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Abstract

We have developed an economical and efficient method for the synthesis of medicinally and synthetically important indole-based triarylmethanes by using indoles and benzhydrols in the presence of propylphosphonic anhydride (T3P(R)). This methodology is an alternate approach for the C-C bond formation with good to excellent yields. In this T3P-mediated dehydration approach, the by-product is highly soluble in water, so that it can be done at larger scale also. In addition to that this efficient protocol has several advantages such as mild reaction conditions, short reaction time and operational simplicity. We have successfully synthesized pyrrole, imidazothiadiazole and imidazolo pyridine based triarylmethanes also.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: Mr Umendra uom
Date Deposited: 15 Feb 2021 10:49
Last Modified: 15 Feb 2021 10:49
URI: http://eprints.uni-mysore.ac.in/id/eprint/15607

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