Structural studies of 2,5-disubstituted 1,3,4-thiadiazole derivatives from dithioesters under the mild condition: Studies on antioxidant, antimicrobial activities, and molecular docking

Gowda, Kemparaje and Swarup, Hassan A. and Nagarakere, Sandhya C. and Rangappa, Shobith and Kanchugarkoppal, Rangappa S. and Kempegowda, Mantelingu (2020) Structural studies of 2,5-disubstituted 1,3,4-thiadiazole derivatives from dithioesters under the mild condition: Studies on antioxidant, antimicrobial activities, and molecular docking. Synthetic Communications, 50 (10). pp. 1528-1544. ISSN 1532-2432

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Abstract

A series of 2,5-disubstituted 1,3,4-thiadiazole was synthesized and evaluated for their antioxidant and molecular docking studies. These molecules were efficiently synthesized under mild and inexpensive starting material. Construction of these molecules developed using substituted aldehydes and substituted dithioesters in presence of NCS (N-Chorosuccinimide). The compounds 4a, 4b, 4c, 4f, and 4k showed good antibacterial and antioxidant activity among which, 4k possess excellent antibacterial and antioxidant activity. The results of antioxidant activity studies revealed that compound 4k manifested profound antioxidant potential. The molecular docking study was performed with respective newly synthesized compounds to ascertain the binding mode of 4k with respect to the critical proteins involved in biosynthesis and metabolic pathways.

Item Type: Article
Uncontrolled Keywords: Aldehyde; antibacterial; docking; NCS; thiadiazole
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Mr Umendra uom
Date Deposited: 18 Feb 2021 07:45
Last Modified: 18 Feb 2021 07:45
URI: http://eprints.uni-mysore.ac.in/id/eprint/15584

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