Caspase Activators: Phytochemicals with Apoptotic Properties Targeting Cancer, a Health Care Strategy to Combat this Disease

Saqib, Asma and Pattar, Sharath and Karigar, Chandrakant Shivappa and Sekhar, Shailasree (2020) Caspase Activators: Phytochemicals with Apoptotic Properties Targeting Cancer, a Health Care Strategy to Combat this Disease. Indian Journal of Pharmaceutical Education and Research, 54 (3). pp. 496-508. ISSN 0019-5464

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Context: Caspases, a family of cysteine-aspartic proteases have a pivotal role in apoptotic pathways. Their down-regulation is reported to induce inappropriate cell survival and enhanced carcinogenic potential. Screening of phytochemicals with a capacity to activate caspases enhancing apoptotic capacity has been proven to be effective anticancer agents. Objectives: This review consolidates data on phtochemicals traditionally used to treat cancerous conditions. The scientific validation of caspase-activated apoptosis for this tradition& application has been compiled. Methods: Internet assisted scientific literature was collected from Google, Google Scholar, Research Gate and NCI, restricted to publications from 1997 to 2019. Search terms `caspases and cancer', `assay of caspases', `traditionally used medicinal plants', `Kani tribes', `plant extracts activating caspase', `cytotoxicity assay', `docking phytochemicals to caspase', `technological advancement for anticancer therapy', `clinical studies of plant extracts and phytochemicals' and `herbal drugs approved by FDA' was included. Results: The compilation revealed significance of multiple experiment& strategies, traditional research laboratory practices and advanced in silico molecular docking techniques in anticancer therapy. Technological advancement such as MALDI-TOF assisted phytochemical mediated protein target identification and designing promoter for caspases activation and synthesizing functionalized nano carriers for clinic& studies has been included for identification of hit molecule and lead optimization. Eugenol and berberine were identified as phytochemicals with potential drug characteristics by both in silico and in vivo studies. Conclusion: The phytochemicals from important Kani tribal medicinal plants via in silico docking and in vivo studies identified could be explored at clinical trials.

Item Type: Article
Uncontrolled Keywords: Anticancer; Apoptosis-associated caspase assay; Advanced in silico techniques; NCI; Kani tribes; HeLa cell lines
Subjects: C Chemical Science > Biochemistry
Divisions: Department of > Institution of Excellence
Depositing User: Mr Umendra uom
Date Deposited: 23 Feb 2021 10:04
Last Modified: 15 Nov 2022 09:26

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