Synthesis and Biological Evaluation of Theophylline Methyl 1,3,4-Oxadiazole as Anticancer Agents

Gopinatha, Vindya K. and Ray, Ujjayinee and Mantelingu, Kempegowda and Raghavan, Sathees C. and Rangappa, Kanchugarakoppal S. (2020) Synthesis and Biological Evaluation of Theophylline Methyl 1,3,4-Oxadiazole as Anticancer Agents. Russian Journal of Bioorganic Chemistry, 46 (5). pp. 837-844. ISSN 1608-330X

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Abstract

A series of theophylline methyl 1,3,4-oxadiazole small molecules were obtained via cyclization of theophylline-7-acetohydrazide with different benzoic acids. The compounds (IVa-j) were synthesized and characterized by using conventional methods. The new compounds obtained were evaluated for their cytotoxic effect in three different cancer lines, the activity obtained varies depending upon the structure of a molecule. The compound (IVb) and (IVf) showed promising effect than other compounds of the series. Thus, these two derivatives have the potential for developing as anticancer agents.

Item Type: Article
Uncontrolled Keywords: theophylline; cytotoxicity; oxadiazole; cancer
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Mr Umendra uom
Date Deposited: 06 Mar 2021 10:29
Last Modified: 06 Mar 2021 10:29
URI: http://eprints.uni-mysore.ac.in/id/eprint/15521

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