Synthesis, Characterization, and Anticancer Studies of Some Pyrazole-Based Hybrid Heteroatomics

Kuthyala, Sharanya and Sheikh, Sareen and Prabhu, Ashwini and Rekha, P. D. and Karikannar, Nagaraja G. and Shankar, Madan K. (2020) Synthesis, Characterization, and Anticancer Studies of Some Pyrazole-Based Hybrid Heteroatomics. Chemistryselect, 5 (35). pp. 10827-10834. ISSN 2365-6549

Full text not available from this repository. (Request a copy)
Official URL:


Defined with a dual-mode of action, the hybrid molecule synthesis is an attractive strategy to endure the scientific challenges in drug discovery. Besides worthy development in cancer therapy, it is still a leading cause of death across the globe. Failure in terms of efficacy, selectivity and toxicity, the statistics of a potential drug to concrete the cancer is rather in bleak. In the present study, synthesized hybrid molecules were well characterized by spectroscopy techniques. The single-crystal X-ray crystallography study revealed the monoclinic crystal system of Dimethyl 1,4-dihydro-2,6-dimethyl-4-(3-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-1H-pyr azol-4-yl)pyridine-3,5-dicarboxylate (5 b) with spacegroupC2/c. MTT assay provided the anticancer property of the compounds Diethyl1,4-dihydro-3,5-dimethyl-4-(3-(5-methyl-1-phenyl-1H-pyrazol-4-yl) -1H-pyrazol-4-yl)pyridine-2,6-dicarboxylate (5 a) and 5-methyl-1-phenyl-4-(4-(4,5-diphenyl-1H-imidazol-2-yl)-1H-pyrazol-3-yl)- 1H-pyrazole (6 a) against A549 cell lines with the IC(50)values of 42.79 mu M and 55.13 mu M respectively. The AO-EB staining assay for cell death analysis confirmed the selective action of both5 aand6 a. Further, molecular docking confirmed the effective binding with cyclin-dependent kinase (CDK2) protein, suggesting that the target compounds are remarkable inhibitors in dysregulating the CDK2 protein in cancer cells.

Item Type: Article
Uncontrolled Keywords: Cell death analysis; crystal growth; Docking; Drug discovery; MTT Assay
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Institution of Excellence
Depositing User: Mr Umendra uom
Date Deposited: 01 Apr 2021 10:11
Last Modified: 01 Apr 2021 10:11

Actions (login required)

View Item View Item