Evaluation of mechanisms of action of re-purposed drugs for treatment of COVID-19

Rajaiah, Rajesh and Abhilasha, Kandahalli and Shekar, Mysore A. and Vogel, Stefanie N. and Vishwanath, Bannikuppe S. (2020) Evaluation of mechanisms of action of re-purposed drugs for treatment of COVID-19. Cellular Immunology, 358. ISSN 1090-2163

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Abstract

Coronavirus disease 2019 (COVID-19) is a global health emergency caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The rapid worldwide spread of SARS-CoV-2 infection has necessitated a global effort to identify effective therapeutic strategies in the absence of vaccine. Among the re-purposed drugs being tested currently, hydroxychloroquine (HCQ), without or with zinc ion (Zn++) and the antibiotic azithromycin (AZM), has been administered to prevent or treat patients with COVID-19. The outcome of multiple clinical studies on HCQ has been mixed. Zn++ interferes with viral replication by inhibiting replicative enzymes and its entry into cells may be facilitated by HCQ. Another immunomodulatory drug, methotrexate (MTX), is well known for its ability to mitigate overactive immune system by upregulating the anti-inflammatory protein, A20. However, its beneficial effect in treating COVID-19 has not drawn much attention. This review provides an overview of the virology of SARS-CoV-2 and an analysis of the mechanisms by which these anti-inflammatory agents may act in the treatment of COVID-19 patients. We propose a rationale for the combinatorial use of these re-purposed drugs that may help to combat this ongoing pandemic health emergency.

Item Type: Article
Uncontrolled Keywords: COVID-19; SARS-CoV-2; Hydroxychloroquine; Methotrexate; Cytokine storm
Subjects: B Life Science > Molecular Biology
Divisions: Department of > Molecular Biology
Depositing User: Mr Umendra uom
Date Deposited: 30 Mar 2021 10:22
Last Modified: 30 Mar 2021 10:22
URI: http://eprints.uni-mysore.ac.in/id/eprint/15468

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