Avvadukkam, Jayashree and Badiadka, Narayana and Kunhanna, Sarojini B. and Kumar, Madan S. (2020) A facile synthesis of pyrano2,3-d:6,5-d `]dipyrimidines via microwave-assisted multicomponent reactions catalyzed by beta-cyclodextrin. Journal of Heterocyclic Chemistry.
Full text not available from this repository. (Request a copy)Abstract
A facile three-component reaction of aromatic aldehyde, 2,2-dimethyl-1,3-dioxane-4,6-dione, and 6-amino-1,3-dimethyluracil was developed for the first time using beta-cyclodextrin (beta-CD) as a macrocyclic host for aldehyde and an efficient catalyst that leads to a batch of novel pyrano2,3-d:6,5-d `]dipyrimidines (4a-k). The synthesis was accomplished with the aid of microwave irradiations in solvent-free conditions. The product obtained was in contrast to the previous report in which a similar reaction resulted in a mixture of benzylidenepyrimidine and bisaminopyrimidine analogs in the presence of triethylbenzylammonium chloride in an aqueous medium. The formation of the pyrano2,3-d:6,5-d `]dipyrimidines may be in virtue of the property of beta-CD to construct new C-C and C-X (where X = heteroatom) bonds. Reusability of the catalyst up to three runs without any noteworthy change in catalytic activity is one of the main features of the reaction. Other noteworthy features are good to excellent yields, eco-friendly procedure, non-column chromatographic purification, and mild conditions.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Mr Umendra uom |
| Date Deposited: | 01 Apr 2021 10:18 |
| Last Modified: | 01 Apr 2021 10:18 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/15455 |
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