Congenital-malformations of the external, middle, and inner-ear produced by isotretinoin exposure in mouse embryos

Jarvis, B. L. and Johnston, M. C. and Sulik, K. K. (1990) Congenital-malformations of the external, middle, and inner-ear produced by isotretinoin exposure in mouse embryos. Otolaryngology-Head and Neck Surgery, 102 (4). pp. 391-401.

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Abstract

Isotretinoin (Accutane), a widely used dermatologic drug, produces severe congenital malformations when used during pregnancy. The isotretinoin teratogen syndrome consists of multiple cardiovascular and craniofacial anomalies, most commonly involving the external ear. This study examined the pathogenesis of isotretinoin teratogenicity in a mouse model, using microdissection and histologic examination of fetal mouse ears after treatment with the drug at various stages of embryonic development. In this study, earlier treatment times frequently produced microtia similar to that seen in affected infants, as well as recognizable patterns of temporal bone and ossicular abnormalities; exposure at a later developmental stage resulted in facial tags with less severely affected ears. Possible teratogenic mechanisms of isotretinoin are discussed. Suitability of the mouse model for studying human congenital craniofacial malformations, such as Goldenhar's and Treacher Collins Syndrome, is also explored.

Item Type:	Article
Uncontrolled Keywords:	Otolaryngology; Otorhinolaryngology; Surgery
Subjects:	B Life Science > Zoology
Divisions:	Department of > Zoology
Depositing User:	Dr Raju C
Date Deposited:	21 Jan 2021 09:48
Last Modified:	25 Jan 2021 06:10
URI:	http://eprints.uni-mysore.ac.in/id/eprint/15384

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