Synthesis and biological efficacy of novel piperazine analogues bearing quinoline and pyridine moieties

Al-Ghorbani, M. and Rekha, N. D. and Ranganatha, V. L. and Prashanth, T. and Veerabasappa Gowda, T. and Khanum, S. A. (2015) Synthesis and biological efficacy of novel piperazine analogues bearing quinoline and pyridine moieties. Russian Journal of Bioorganic Chemistry, 41 (5). pp. 554-561. ISSN 1608-330X

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Abstract

A series of novel piperazine analogues bearing quinolin-8-yloxy-butan-1-ones/pyridin-2-yloxyethanones were synthesized by a simple and convenient approach based on various substituted piperazine incorporating quinoline and pyridine moieties. The analogues were evaluated for in vitro antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferrous ion radical scavenging activities and anti-inflammatory activity by inhibition of Vipera russelli venom (PLA(2)) and gastric K+/H+-ATPase activities. Most of the title compounds exhibited promising activity. Best antioxidant and PLA(2)-inhibiting activities were found for piperazine analogues with phenyl and nitro phenyl groups, whereas methoxy group on phenyl piperazine indicated selectivity for the H+/K+-ATPase.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Users 19 not found.
Date Deposited:	31 May 2019 10:09
Last Modified:	22 Dec 2020 05:23
URI:	http://eprints.uni-mysore.ac.in/id/eprint/1495

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