Paf-acether (PAF) in ehrlich ascites tumor-cells

Marathe, G. K. and Krishnakanta, T. P. and D'Souza, C. J. M. (1992) Paf-acether (PAF) in ehrlich ascites tumor-cells. Journal of Lipid Mediators, 2 (5). pp. 257-262.

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PAF-acether fraction of Ehrlich ascites tumour cells stimulated with the calcium ionophore A23187 aggregated human platelets. The platelet aggregating ability increased with increasing concentration of ionophore and reached a maximum at 10 microM in 30 min. The phosphatidylcholine fraction from unstimulated cells after alkaline methanolysis followed by acetylation also aggregated human platelets. This semisynthetic preparation had biological and chemical properties identical to authentic PAF-acether. Our results show that Ehrlich ascites tumour cells produce PAF-acether in response to ionophore stimulation.

Item Type: Article
Subjects: C Chemical Science > Biochemistry
Divisions: Department of > Biochemistry
Depositing User: Dr Raju C
Date Deposited: 21 Jan 2021 09:57
Last Modified: 09 May 2023 07:25

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