Basavaiah, K. and Prameela, H. C. and Chandrashekar, U. (2003) Simple High-performance Liquid Chromatographic Method for the Determination of Acyclovir in Pharmaceuticals. IL Farmaco, 58 (12). pp. 1301-1306. ISSN 0014-827X
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An assay method for the determination of acyclovir from pharmaceutical preparations has been developed for assessment of product quality utilising high-performance liquid chromatography. The chromatographic conditions comprised a reversed-phase C18 column (250×4.6 mm i.d.) with a mobile phase of acetonitrile-20 mmol l−1 aqueous ammonium acetate buffer of pH 4.5 (40:60). The flow rate was 0.8 ml min−1 and UV detection was used at 250 nm. Calibration graph was linear in the range 1.98–59.4 μg ml−1. The method has been validated according to current guidelines including assay of pharmacopoeial standard tablets. Recoveries ranged from 96.64 to 99.53%. The exipients present in the tablets did not interfere with the method.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Acyclovir and High-performance liquid chromatography and Pharmaceutical product and Quality assessment |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | LA manjunath user |
| Date Deposited: | 22 Dec 2020 05:41 |
| Last Modified: | 22 Dec 2020 05:41 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/14262 |
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