Snake venom induced local toxicities: plant secondary metabolites as an auxiliary therapy.

Santhosh, M. S. and Hemshekhar, M. and Sunitha, K. and Thushara, R. M. and Jnaneshwari, S. and Kemparaju, K. and Girish, K. S. (2013) Snake venom induced local toxicities: plant secondary metabolites as an auxiliary therapy. Mini-Reviews in Medicinal Chemistry, 13 (1, Cop). pp. 106-123. ISSN 1389-5575

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Official URL: http://dx.doi.org/10.2174/138955713804484730

Abstract

A review. Snakebite is a serious medical and socio-economic problem affecting the rural and agricultural laborers of tropical and sub-tropical region across the world leading to high morbidity and mortality. In most of the snakebite incidences, victims usually end up with permanent tissue damage and sequelae with high socioeconomic and psychol. impacts. Although, mortality has been reduced markedly due to anti-venom regimen, it is assocd. with several limitations. Snake venom metalloprotease, hyaluronidase and myotoxic phospholipase A2 are the kingpins of tissue necrosis and extracellular matrix degrdn. Thus, inhibition of these enzymes is considered to be the rate limiting step in the management of snakebite. Unfortunately, tissue necrosis and extracellular matrix degrdn. persists even after the administration of anti-venom. At present, inhibitors from snake serum and plasma, several synthetic compds. and their analogs have been demonstrated to possess anti-snake venom activities, but the use of plant metabolites for this purpose has an added advantage of traditional knowledge and will make the treatment cheaper and more accessible to the affected population. Therefore, the clin. and research forums are highly oriented towards plant metabolites and interestingly, certain phytochems. are implicated as the antibody elicitors against venom toxicity that can be exploited in designing effective anti-venoms. Based on these facts, we have made an effort to enlist plant based secondary metabolites with anti-ophidian abilities and their mechanism of action against locally acting enzymes/toxins in particular. The review also describes their functional groups responsible for therapeutic beneficial and certainly oblige in designing potent inhibitors against venom toxins. [on SciFinder(R)]

Item Type: Article
Additional Information: Unmapped bibliographic data: PY - 2013/// [EPrints field already has value set] JA - Mini-Rev. Med. Chem. [Field not mapped to EPrints]
Uncontrolled Keywords: review snake venom antivenom secondary metabolite drug design
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
Depositing User: Kodandarama
Date Deposited: 06 Jul 2013 07:34
Last Modified: 06 Jul 2013 07:34
URI: http://eprints.uni-mysore.ac.in/id/eprint/13214

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