Evaluation and studies on the structural impact of 3-aryl-5-(4-methoxyphenyl)-4,5-dihydroisoxazole-4-carbonitriles on their biological activities.

Prabhashankar, J. and Govindappa, V. K. and Renuka, N. and Akshatha, K. N. and Mahadevamurthy, S. and Kariyappa, A. K. (2012) Evaluation and studies on the structural impact of 3-aryl-5-(4-methoxyphenyl)-4,5-dihydroisoxazole-4-carbonitriles on their biological activities. Pharmacia Lettre, 4 (6, Cop). pp. 1685-1691. ISSN 0975-5071

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Abstract

In present study, a series of isoxazole derivs. was synthesized and evaluated for antibacterial and antifungal activities by disk diffusion method using different bacterial and fungal strains. Some compds. of the series exhibited promising antibacterial and antifungal activity compared to std. drugs. The min. inhibitory concn. (MIC's) was detd. against each organism. The compds. were tested for their antioxidant activity and reducing power ability. Free radicals play an important role in various pathol. and xenotoxic effects so antioxidant may have protective role in these pathol. conditions. Based on the results of an antimicrobial, anti-oxidant study, the effect of substitution on the activity and possible structure activity relationship of the compds. for their antioxidant activity is presented. [on SciFinder(R)]

Item Type: Article
Additional Information: Unmapped bibliographic data: PY - 2012/// [EPrints field already has value set] JA - Pharm. Lett. [Field not mapped to EPrints]
Uncontrolled Keywords: isoxazole deriv antibacterial antifungal structure activity relationship bacteria fungus
Subjects: Physical Sciences > Chemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Chemistry
Depositing User: Kodandarama
Date Deposited: 24 Jun 2013 05:35
Last Modified: 24 Jun 2013 05:35
URI: http://eprints.uni-mysore.ac.in/id/eprint/12866

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