A new HPLC method for the quantification of pantoprazole in pharmaceuticals.

Basavaiah, K. and Anil Kumar, U. R. and Tharpa, K. (2008) A new HPLC method for the quantification of pantoprazole in pharmaceuticals. International Journal of Chemical Sciences, 6 (2, Cop). pp. 579-586. ISSN 0972-768X

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Abstract

A new anal. method is developed and appropriately validated by means of a high performance liq. chromatog. (HPLC) in reverse phase to quantify pantoprazole in pharmaceutical prepns. The HPLC detn. was performed on a reversed phase column (Inertsil ODS 5 μm; 150 × 4.6 mm i.d) using a mobile phase (0.6 mL/min-1) with UV-detection at 289 nm. A rectilinear relationship between mean peak area and concn. of PNT was obsd. in the range 25-200 μg/mL-1 with a detection limit of 6.0 μg/mL-1 and a quantitation limit of 20.0 μg/mL-1. Intra-day and inter-day precision, and accuracy of the methods have been established according to the current ICH guidelines. The results were statistically compared with those of the ref. method by applying Student's t-test and F-test. Accuracy, evaluated by means of the spike recovery method was in the range 97.7-102.2%, with precision (RSD) better than 2%. [on SciFinder(R)]

Item Type: Article
Additional Information: Unmapped bibliographic data: PY - 2008/// [EPrints field already has value set] JA - Int. J. Chem. Sci. [Field not mapped to EPrints]
Uncontrolled Keywords: high performance liq chromatog pantoprazole pharmaceutical
Subjects: Physical Sciences > Chemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Chemistry
Depositing User: Dhruvakumar
Date Deposited: 10 Jun 2013 07:51
Last Modified: 07 Dec 2015 11:27
URI: http://eprints.uni-mysore.ac.in/id/eprint/12307

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