Order versus disorder in two isomorphous pyrazolone-substituted di­ethyl propane­dioates prepared using a three-component one-pot reaction under solvent-free conditions

Shreekanth, Tharangini K. and Yathirajan, H. S. and Kalluraya, Balakrishna and Foro, Sabine and Glidewell, Christopher (2020) Order versus disorder in two isomorphous pyrazolone-substituted di­ethyl propane­dioates prepared using a three-component one-pot reaction under solvent-free conditions. Acta Crystallographica Section E, 76 (10). pp. 1605-1610. ISSN 2056-9890

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Official URL: https://doi.org/10.1107/S2056989020011676

Abstract

Two new substituted propane­dioate esters have been synthesized using a three-component solvent-free thermal reaction between diethyl propane­dioate (diethyl malonate), 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde and an aryl azide, forming two new C—C bonds in a single step. The products diethyl (RS)-2-[(4-bromo­phen­yl)(5-methyl-3-oxo-2-phenyl-2,3-di­hydro-1H-pyrazol-4-yl)meth­yl]propane­dioate, C24H25BrN2O5 (I), and diethyl (RS)-2-[(4-chloro­phen­yl)(5-methyl-3-oxo-2-phenyl-2,3-di­hydro-1H-pyrazol-4-yl)meth­yl]propane­dioate, C24H25ClN2O5 (II), are isomorphous, with Z′ = 2 in space group P21/n. The two independent mol­ecules in compound (I) are both fully ordered, while each of the independent mol­ecules in compound (II) is disordered, but in different ways. In one mol­ecule of (II), the N-phenyl ring is disordered over two sets of atomic sites having occupancies 0.635 (10) and 0.365 (10), and in the other mol­ecule the ester function is disordered over two sets of atomic sites having occupancies 0.690 (5) and 0.310 (5). In both structures, the two independent mol­ecules adopt different conformations and, in each structure, the mol­ecules are linked into complex sheets by a combination of N—H⋯O, C—H⋯O and C—H⋯π(arene) hydrogen bonds. Comparisons are made with some related structures.

Item Type: Article
Uncontrolled Keywords: synthesis, pyrazoles, crystal structure, disorder, molecular conformation, hydrogen bonding, supramolecular assembly
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: MUL SWAPNA user
Date Deposited: 10 Dec 2020 05:40
Last Modified: 10 Dec 2020 05:40
URI: http://eprints.uni-mysore.ac.in/id/eprint/12132

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