Phytogenic synthesis of nanoparticles from Rhizophora mangle and their bactericidal potential with DNA damage activity

Syed, Baker and Bisht, Nalini and Bhat, Prithvi S. and Nikhil Karthik, R. and Prasad, Ashwini and Dhananjaya, B. L. and Satish, S. and Prasad, Hara and Nagendra Prasad, M. N. (2017) Phytogenic synthesis of nanoparticles from Rhizophora mangle and their bactericidal potential with DNA damage activity. Nano-Structures & Nano-Objects, 10. 112 - 115. ISSN 2352-507X

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Official URL: https://doi.org/10.1016/j.nanoso.2017.03.011

Abstract

The present study reports phytogenic synthesis of nanoparticles using aqueous extract of Rhizophora mangle. The synthesized nanoparticles were characterized using UV–Visible spectroscopy with maximum absorption at 400 nm. Fourier Transform Infrared spectroscopy (FT-IR) studies revealed the presence of functional groups mediating the synthesis of nanoparticles. X-ray diffraction (XRD) displayed Bragg’s intensities at 2θ angle which confirmed the crystalline nature of the nanoparticles. Transmission Electron Microscopy (TEM) revealed size and shape of the nanoparticles with polydispersity of nanoparticles and size of 10–60 nm. The synthesized nanoparticles expressed antibacterial activity by well diffusion assay, broth micro dilution assay, minimal inhibitory concentration and CFU assay against selective human pathogens. Nanoparticles were more effective against S. aureus (MTCC 7443) followed by B. subtilis (MTCC 121), E. coli (MTCC 7410) and S. typhi (MTCC 7407). The possible mode of action of nanoparticles was studied by treating silver nanoparticles with pathogenic DNA which showed defamed and damage DNA in comparison with control DNA.

Item Type: Article
Uncontrolled Keywords: Phytogenic,Nanoparticles, Bactericidal, DNA damage
Subjects: B Life Science > Microbiology
Divisions: Department of > Microbiology
Depositing User: MUL SWAPNA user
Date Deposited: 10 Mar 2020 05:04
Last Modified: 10 Mar 2020 05:04
URI: http://eprints.uni-mysore.ac.in/id/eprint/11893

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