A facile spectrophotometric determination of metoclopramide hydrochloride in pharmaceutical dosage forms.

Ramappa, P. G. and Revanasiddappa, H. D. (1999) A facile spectrophotometric determination of metoclopramide hydrochloride in pharmaceutical dosage forms. Indian Drugs, 36 (6, Cop). pp. 381-384. ISSN 0019-462X

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Abstract

Two simple, rapid and sensitive spectrophotometric methods for the detn. of metoclopramide in bulk and dosage forms, are described. The first method was based on the interaction of diazotized drug with chromotropic acid (CTA) in an alk. medium. The second was based on oxidative coupling of the drug with 3-methylbenzothiazolin-2-one hydrazone (MBTH) in the presence of cerium (IV) in 1M sulfuric acid. The resulting chromophores were measured at 540 nm of the CTA method or at 560 nm for the MBTH method. The proposed methods were applied for the assay of the drug in pharmaceuticals formulations such as Perinorm and Reglan, and the results demonstrated that the methods are equally accurate, precise and reproducible as the official methods. [on SciFinder(R)]

Item Type: Article
Additional Information: Unmapped bibliographic data: PY - 1999/// [EPrints field already has value set] JA - Indian Drugs [Field not mapped to EPrints]
Uncontrolled Keywords: spectrophotometric detn metoclopramide pharmaceutical
Subjects: Physical Sciences > Chemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Chemistry
Depositing User: Kruthi M.S
Date Deposited: 01 Jun 2013 06:13
Last Modified: 01 Jun 2013 06:13
URI: http://eprints.uni-mysore.ac.in/id/eprint/11783

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