Spectrophotometric analysis of some phenothiazine neuroleptics using chloramine-T

Basavaiah, K. and Swamy, J. M. and Krishnamurthy, G. (1999) Spectrophotometric analysis of some phenothiazine neuroleptics using chloramine-T. Analytical Letters, 32 (13). pp. 2613-2623. ISSN 0003-2719

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A sensitive and selective spectrophotometric method has been developed for the determination of six phenothiazine neuroleptics. The method is based on the interaction of the drugs with chloramine-T in sulphuric acid medium to yield a red reddish-violet, orange or greenish-blue intermediate with maximum absorption at 500-636 nm. Beer's law is obeyed over the range 5-125 mu g ml(-1) of the drugs. The apparent molar absorptivities were found to be in the range 1.04x10(3) to 5.46x10(3) l.mol(-1) cm(-1). The investigated drugs were assayed in tablets and injections. The mean percentage recoveries were 97.65-101.75 and the relative standard deviations were found to be less than 2%.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Vasantha uom
Date Deposited: 05 Feb 2020 11:17
Last Modified: 05 Feb 2020 11:17
URI: http://eprints.uni-mysore.ac.in/id/eprint/11151

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